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Trends Neurosci 1992 Jul;15(7):254-9

Mechanoelectrical transduction by hair cells.

Pickles JO, Corey DP

Dept of Physiology and Pharmacology, University of Queensland, Australia.

Hair cells of the inner ear are one of nature's great success stories, appearing early in vertebrate evolution and having a similar form in all vertebrate classes. They are specialized columnar epithelial cells, with an array of modified microvilli or stereocilia on their apical surface, interconnected by a series of linkages. The mechanical stimulus causes deflection of the stereocilia, stretching linkages between them, and opening the mechanotransducer channels. On a slower timescale, hair cells adapt in order to maintain optimum sensitivity, with an adaptation motor within the stereocilia acting to keep the resting tension on channels constant.

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PMID: 1381121, UI: 92383708

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