Cell 1994 Nov 18;79(4):705-15
Salk Institute for Biological Studies, La Jolla, California
We report the isolation and functional characterization of
a member of the nicotinic acetylcholine receptor subunit gene
family, alpha 9. Xenopus oocytes injected with alpha 9 cRNA express
a homomeric receptor-channel complex that is activated by acetylcholine.
The alpha 9 receptor displays an unusual mixed nicotinic-muscarinic
pharmacological profile. The unique properties of the alpha 9
receptor-channel complex closely match those described for the
cholinergic receptor present in vertebrate cochlear hair cells.
In situ hybridization studies reveal a restricted pattern of alpha
9 gene expression that includes the outer hair cells of the rat
cochlea. Our results suggest that the alpha 9 receptor is involved
in the cholinergic efferent innervation of cochlear hair cells
and thus may modulate the encoding of auditory stimuli.
PMID: 7954834, UI: 95042767
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