Neurosci Lett 1998 Nov 13;256(3):155-8
Section of Otolaryngology and Neurobiology, Yale University
School of Medicine, New Haven, CT 06510, USA. firstname.lastname@example.org
Whole cell voltage clamp and freeze fracture were used to study
the electrophysiological and ultrastructural correlates of the
outer hair cell (OHC) lateral membrane molecular motors. We find
that specific voltage-dependent capacitance, which derives from
motility-related charge movement, increases as cell length decreases.
This increasing non-linear charge density predicts a corresponding
increase in sensor-motor density. However, while OHC lateral membrane
particle density increases, a quantitative correspondence is absent.
Thus, the presumed equivalence of particle and motor is questionable.
The data more importantly indicate that whereas the voltage driving
OHC motility, i.e. the receptor potential, may decrease with frequency
due to the OHC's low-pass membrane filter, the electrical energy
(Q x V) supplied to the lateral membrane will tend to remain stable.
This conservation of energy delivery is likely crucial for the
function of the cochlear amplifier at high frequencies.
PMID: 9855363, UI: 99071005
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