Pathology of hair cells and neurons
Overview/ Aminoglycosides/ Noise trauma/ Excitotoxicity/ Presbycusis/ Tinitus

Principales references

Pathology of cochlear hair cells and neurones

Reviewsvues :

a1. Norris CH (1988) Drugs affecting the inner ear. A review of their clinical efficacy, mechanisms of action, toxicity, and place in therapy. Drugs ;36(6):754-72
Huang MY, Schacht J (1989) Drug-induced ototoxicity. Pathogenesis and prevention. Med Toxicol Adverse Drug Exp 4(6):452-67
STEEL KP, BROWN DM (1996) Genetics of deafness. Current Opinion in Neurobiol., 6: 520-525
a4. PETIT C (1996) Genes responsible for human hereditary deafness: symphony of a thousand. Nature Genetics, 14: 385-389

a5. Holme RH, Steel KP (1999) Genes involved in deafness. Curr Opin Genet Dev 9(3):309-314


a11. EGGERMONT JJ, BOCK GR (1985) Normal and abnormal development of hearing and its clinical implications. Acta Otolaryngol (Stockh) Suppl 421.

Aminoglycoside ototoxicity

b1. Wersall J (1984) Recent otological evaluation of aminoglycoside antibiotics. J Antimicrob Chemother ;13 Suppl A:31-6
Tran Ba Huy P, Deffrennes D (1988) Aminoglycoside ototoxicity: influence of dosage regimen on drug uptake and correlation between membrane binding and some clinical features. Acta Otolaryngol (Stockh);105(5-6):511-5
b3. Dulon D, Aran JM, Zajic G, Schacht J (1993) Comparative uptake of gentamicin, netilmicin, and amikacin in the guinea pig cochlea and vestibule. Antimicrob Agents Chemother ;30(1):96-100
b4. Schacht J (1998) Aminoglycoside ototoxicity: prevention in sight?
Otolaryngol Head Neck Surg ;118(5):674-7


c1.PUJOL R, LENOIR M, ROBERTSON D, EYBALIN M, JOHNSTONE BM (1985) Kainic acid selectively alters auditory dendrites connected with cochlear inner hair cells. Hear Res 18:145-151.
c2.PUJOL R, PUEL J-L, EYBALIN M (1992) Implication of non-NMDA and NMDA receptors in cochlear ischemia. Neuroreport 3:299-302.
c3.PUEL J-L, PUJOL R, TRIBILLAC F, LADRECH S, EYBALIN M (1994) Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity. J Comp Neurol 341:241-256.
c4.PUEL J.-L, SAFIEDDINE S, GERVAIS D'ALDIN C, EYBALIN M, PUJOL R (1995) Synaptic regeneration and functional recovery after excitotoxic injury in the guinea pig cochlea. CR Acad Sci Paris, ser III, Sciences de la Vie/Life Sciences 318:67-75.
c5. Puel JL, Ruel J, Gervais d'Aldin C, Pujol R (1988) Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss. Neuroreport ;9(9):2109-14

Acoustic trauma


Dancer A (1991) Le traumatisme acoustique. Médecine/Sciences 7:357-367.
d2. Dancer A (1993) Effet du bruit sur la transduction acoustique. C R Soc Biol., 187(5): 650-65
d3. Henderson D, Hamernik RP, Biologic bases of noise-induced hearing loss. Occup Med 1995 Jul-Aug;10(3):513-34


Basic and applied aspects of noise-induced hearing loss. Salvi, Henderson, Hamernick and Colletti eds., Plenum, NY, 1986.
d12.Scientific basis of noise induced hearing loss. Axelsson; Hellstrom, Borchgrevink, Henderson, Hamernik and Salvi eds, Thieme,NY, 1996.

...and also

d21. Cody AR and Russell IJ, Outer hair cells in the cochlea and noise induced hearing loss. Nature 315, 662-665, 1985.
d22. Zhao Y, Yamoah EN, Gillespie PG, Regeneration of broken tip links and restoration of mechanical transduction in hair cells. Proc Natl Acad Sci U S A 1996 Dec 24;93(26):15469-74
d23. Chan E, Suneson A, Ulfendahl M, Acoustic trauma causes reversible stiffness changes in auditory sensory cells. Neuroscience 1998 Apr;83(3):961-8
d24. Patuzzi R, Exponential onset and recovery of temporary threshold shift after loud sound: evidence for long-term inactivation of mechano-electrical transduction channels. Hear Res 1998 Nov;125(1-2):17-38
d25. Puel JL, Ruel J, Gervais d'Aldin C, Pujol R, Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss. Neuroreport 1998 Jun 22;9(9):2109-14
d26. Flock A, Flock B, Fridberger A, Scarfone E, Ulfendahl M, Supporting cells contribute to control of hearing sensitivity. J Neurosci 1999 Jun 1;19(11):4498-507



e1. Hawkins, JE Jr, 1973. Comparative pathology: aging, noise and ototoxic drugs. Adv. Otolaryngol. 20: 125-141
e2. Schuknecht HF, Gacek MR (1993) Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol ;102(1 Pt 2):1-16
e3. Willott JF (1996) Anatomic and physiologic aging: a behavioral neuroscience perspective. JAm Acad Audiol ;7(3):141-51


Han, SS and Coons, BS. 1977. Special senses in aging. Univ. Michigan Press



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